The Medical University of South Carolina (MUSC) Board of Trustees on Friday advanced the MUSC Downtown Charleston Campus Master Plan, a long-term framework designed to guide the future evolution of MUSC’s historic campus.
Centered on thoughtful urban design, connectivity and community well-being, the master plan intentionally stitches MUSC’s campus into the surrounding city fabric through inviting public spaces, expanded green infrastructure and improved pedestrian and multimodal mobility. Resilient design, such as integrated stormwater management, landscaped open spaces and adaptive infrastructure, enhance both environmental performance and quality of life. Together, these plans support a vision made possible through ongoing collaboration between MUSC and the city of Charleston.
“This roadmap allows us to think holistically about how we invest where it matters most,” said David Cole, M.D., FACS, president of MUSC. “It prioritizes the delivery of the highest-acuity clinical care while expanding capacity for cutting-edge research and academic excellence.”
The plan includes major initiatives currently underway, such as new buildings for both the College of Health Professions and the College of Medicine, a comprehensive cancer hospital and a medical office building/ambulatory surgery center at 334 Calhoun St.
Through this master plan, MUSC reaffirms its commitment to improving the health of the communities it serves while shaping the future of health care across the region and nation. This helps prioritize thoughtful campus evolution by strengthening education, research and clinical adjacencies.
“As we are increasing our primary care capabilities and access to clinical trials across the state, the plan positions our downtown campus to continue serving South Carolina as a center for complex care, discovery and education while planning responsibly for the future,” said Cole.
Created by leading global interdisciplinary architecture and design firm Perkins & Will, in collaboration with McMillan Pazdan Smith, the plan reflects MUSC’s commitment to strengthening resiliency and sustainability, including green space, storm water mitigation, energy requirements, infrastructure and more.
The master plan is a long-range planning tool, not a construction timeline. Any future projects would be phased and subject to review and approvals. Updates will be shared on an ongoing basis at www.musc.edu/campus-master-

